| Cat. No. |
Product Name |
Information |
| PC-23343 |
Batimastat
MMP inhibitor
|
Batimastat (BB94) is a potent broad spectrum matrix metalloproteinase (MMP) inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
| PC-21808 |
ADAM9i
ADAM9 inhibitor
|
ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. |
| PC-21753 |
BAY-9835
ADAMTS7 inhibitor
|
BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively. |
| PC-21093 |
GM6001
MMP inhibitor
|
GM6001 (Ilomastat) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 of 1.5/1.1/1.9/0.5 nM for MMP-1/2/3/9, respectively. |
| PC-20540 |
MMP408
MMP-12 inhibitor
|
MMP408 (MMP 408) is a potent, selective matrix metalloprotease 12 (MMP-12) inhibitor with IC50 of 2.0 nM (human MMP-12), 60-fold selectivity over MMP-13. |
| PC-20539 |
AZD1236
MMP-9/12 inhibitor
|
AZD1236 is a potent, selective MMP-9 and MMP-12 inhibitor with IC50 of 4.5 and 6.1 nM respectively, >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other MMPs. |
| PC-20538 |
MMP118
MMP-12 inhibitor
|
MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively. |
| PC-20536 |
CM-352
MMP-3/MMP-10 inhibitor
|
CM-352 (CM352) is an antihemorrhagic agent that potently inhibit MMP-10 and MMP-3 (IC50 of 12 and 15 nM, respectively), inhibits fibrinolysis in human whole blood functional assays with EC50 of 0.7 nM. |
| PC-20535 |
Trimeric MMP-9 inhibitor 7
MMP-9 inhibitor
|
Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM. |
| PC-20476 |
JTP-96193
TACE inhibitor
|
JTP-96193 (JTP96193) is a potent, selective TNF-α converting enzyme (TACE/ADAM17) inhibitor with IC50 of 5.4 nM, >1800-fold selectivity against ADAM10. |
| PC-38902 |
TP0556351
MMP2 inhibitor
|
TP0556351 is a highly potent, selective matrix metalloproteinase-2 (MMP2) inhibitor with IC50 of 0.2 nM. |
| PC-73394 |
GLPG1972
ADAMTS5 inhibitor
|
GLPG1972 (Aldumastat, S201086) is a potent and selective small-molecule inhibitor of ADAMTS5 with IC50 of 19 and <23 nM against human and rat ADAMTS5, respectively. |
