| Cat. No. |
Product Name |
Information |
| PC-25874 |
INCB3619
ADAM10/ADAM17 inhibitor
|
INCB3619 (INCB-3619) is a potent, selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. |
| PC-25431 |
ADAM17 inhibitor 2155-17
ADAM17 inhibitor
|
ADAM17 inhibitor 2155-17 is a specific small molecule ADAM17 inhibitor with IC50 of 4.3 uM, with no activity against MMP2, MMP8, MMP9 ,MMP14, and ADAM10 (IC50>100 uM). |
| PC-24822 |
FLF-15
ADAM17 inhibitor
|
FLF-15 is a potent, selective ADAM17 inhibitor with IC50 of 10.43 nM, selectively inhibits its IL-6R cleavage activity, inhibits HCC migration and invasion in vitro and in vivo. |
| PC-24146 |
Linvemastat
MMP-12 inhibitor
|
Linvemastat is a potent, selective matrix metalloproteinase MMP-12 inhibitor. |
| PC-23272 |
GHK-Cu
Wound repair activator
|
GHK-Cu (glycyl-L-histidyl-L-lysine Cu2+ tripeptide) is a growth factor for differentiated cells and a potential activator of wound repair, increases extracellular matrix accumulation, increases MMP-2 levels in conditioned media of cultured fibroblasts.| |
| PC-23169 |
Doxycycline hydrochloride
NS2B-NS3 inhibitor
|
Doxycycline hydrochloride is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor, also is the orthoflaviviral NS2B-NS3 protease inhibitor, shows antiviral and anti-cancer cell proliferation activities. |
| PC-23168 |
Doxycycline
NS2B-NS3 inhibitor
|
Doxycycline is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor, also is the orthoflaviviral NS2B-NS3 protease inhibitor, shows antiviral and anti-cancer cell proliferation activities. |
| PC-23034 |
ADAMTS-IN-1
ADAMTS-4/ADAMTS-5 inhibitor
|
ADAMTS-IN-1 is a potent dual inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively, example 37-2 in Patent WO2021158626 A. |
| PC-23033 |
ADAMTS-5 inhibitor 12
ADAMTS-5 Inhibitor
|
ADAMTS-5 inhibitor 12 is a potent selective ADAMTS-5 (aggrecanase-2) inhibitor with IC50 of 1.1 uM, >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1). |
| PC-22949 |
ADAMTS7 inhibitor 3a
ADAMTS7 inhibitor
|
ADAMTS7 inhibitor 3a is a potent, selective ADAMTS7 inhibitor with Ki of 9 nM, 12-fold selective over ADAMTS5 (Ki=110 nM). |
| PC-22948 |
EDV33
ADAMTSs inhibitor
|
EDV33 is a potent, non-selective inhibitor of ADAMTSs with Ki app value of 68, 31, 6.5, 4.3 and 4.0 nM for ADAMTS-7, ADAMTS-4, ADAMTS-5, ADAM-17 and MMP-2 respectively. |
| PC-22883 |
Aderamastat
MMP-12 inhibitor
|
Aderamastat (FP-025) is a potent, selective and orally active matrix metalloproteinase 12 (MMP-12) inhibitor, 90-fold selectivity over MMP-2 and 200-300 fold selectivity over other MMP family members. |
