| Cat. No. |
Product Name |
Information |
| PC-25876 |
Aderbasib
ADAM10/ADAM17 inhibitor
|
Aderbasb (INCB7839) is a potent, selective inhibitor of ADAM10 and ADAM17, inhibits EGFR ligand shedding from tumor cells, exhibits robust antineoplastic activity. |
| PC-25875 |
KP-457
ADAM17 inhibitor
|
KP-457 (KP-457) is a potent, selective ADAM17 inhibitor with IC50 of 11.1 nM, >50 times more selective for ADAM17 than for other MMPs and ADAM10. |
| PC-25874 |
INCB3619
ADAM10/ADAM17 inhibitor
|
INCB3619 (INCB-3619) is a potent, selective and orally active ADAM10/17 inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. |
| PC-24822 |
FLF-15
ADAM17 inhibitor
|
FLF-15 is a potent, selective ADAM17 inhibitor with IC50 of 10.43 nM, selectively inhibits its IL-6R cleavage activity, inhibits HCC migration and invasion in vitro and in vivo. |
| PC-23343 |
Batimastat
MMP inhibitor
|
Batimastat (BB94) is a potent broad spectrum matrix metalloproteinase (MMP) inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
| PC-21808 |
ADAM9i
ADAM9 inhibitor
|
ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. |
| PC-21753 |
BAY-9835
ADAMTS7 inhibitor
|
BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively. |
| PC-21674 |
TP0628103
MMP-7 inhibitor
|
TP0628103 is a highly potent, selective matrix metalloproteinase-7 (MMP-7) inhibitor with IC50 of 0.17 nM and 4.1 nM for human and mouse MMP-7, respectively. |
| PC-21093 |
GM6001
MMP inhibitor
|
GM6001 (Ilomastat) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 of 1.5/1.1/1.9/0.5 nM for MMP-1/2/3/9, respectively. |
| PC-21092 |
TAPI-1
ADAM17 inhibitor
|
TAPI-1 is a small molecule inhibitor of TNFalpha converting enzyme (TACE, ADAM7), blocks the shedding of several cell surface proteins. |
| PC-20621 |
CID 3117694
ADAM10 inhibitor
|
CID 3117694 is a selective, non-competitive inhibitor of ADAM10 with IC50 of 1.1 uM, does not inhibit ADAM17. |
| PC-20540 |
MMP408
MMP-12 inhibitor
|
MMP408 (MMP 408) is a potent, selective matrix metalloprotease 12 (MMP-12) inhibitor with IC50 of 2.0 nM (human MMP-12), 60-fold selectivity over MMP-13. |
