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Chemical Structure : JTP-96193
Catalog No.: PC-20476Not For Human Use, Lab Use Only.
JTP-96193 (JTP96193) is a potent, selective TNF-α converting enzyme (TACE/ADAM17) inhibitor with IC50 of 5.4 nM, >1800-fold selectivity against ADAM10.
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JTP-96193 (JTP96193) is a potent, selective TNF-α converting enzyme (TACE/ADAM17) inhibitor with IC50 of 5.4 nM, >1800-fold selectivity against ADAM10.
JTP-96193 also displays >500-fold selectivity against other MMP family members such as MMP-1, -2, -3, -7, -8, -9, -10, -12, -13, -15, -16, -17, and -24.
JTP-96193 (10 uM) completely inhibited LPS-induced TNF-α production in rat whole, with IC50 of 0.17 uM.
JTP-96193 significantly inhibited TNF-α production in Lewis rats induced by LPS injection with ED50 3.8 mg/kg.
JTP-96193 dose-dependently reduced the TNF-α release from fat tissue in DIO mice, prevented delay of sciatic MNCV without any effects on blood glucose or insulin levels in STZ-induced diabetic mice.
| M.Wt | 525.60 | |
| Formula | C26H28FN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maekawa M, et al. Biol Pharm Bull. 2019;42(11):1906-1912.
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