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Chemical Structure : AZD1236
Catalog No.: PC-20539Not For Human Use, Lab Use Only.
AZD1236 is a potent, selective MMP-9 and MMP-12 inhibitor with IC50 of 4.5 and 6.1 nM respectively, >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other MMPs.
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AZD1236 (AZD-1236) is a potent, selective MMP-9 and MMP-12 inhibitor with IC50 of 4.5 and 6.1 nM respectively, >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other MMPs.
AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues.
AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg in acute models of lung injury.
AZD1236 also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.
| M.Wt | 402.85 | |
| Formula | C15H19ClN4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Magnussen H, et al. Pulm Pharmacol Ther. 2011 Oct;24(5):563-70.
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