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Chemical Structure : BAY-9835
Catalog No.: PC-21753Not For Human Use, Lab Use Only.
BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively.
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BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively.
BAY-9835 displays >1000-fold selectivity over ADAMTS4/ADAMTS5, and >300-fold selective over ADAM8/10/17, and MMP2/12/14/15.
BAY-9835 shows low clearance, high oral bioavailability, and good tolerability in a 2-week toxicology study in rats.
| M.Wt | 493.39 | |
| Formula | C22H16F5N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Meibom D, et al. J Med Chem. 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c02036.
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