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CM-352

Chemical Structure : CM-352

CAS No.: 1664361-37-8

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CM-352 (CM352)

Catalog No.: PC-20536Not For Human Use, Lab Use Only.

CM-352 (CM352) is an antihemorrhagic agent that potently inhibit MMP-10 and MMP-3 (IC50 of 12 and 15 nM, respectively), inhibits fibrinolysis in human whole blood functional assays with EC50 of 0.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CM-352 (CM352) is an antihemorrhagic agent that potently inhibit MMP-10 and MMP-3 (IC50 of 12 and 15 nM, respectively), inhibits fibrinolysis in human whole blood functional assays with EC50 of 0.7 nM.
    CM-352 displays no significant acitvity against a panel of 84 different protein targets bearing metal-binding sites (e.g., cathepsins, caspases, HDACs, etc.) at 10 uM.
    CM-352 behaved as a pan-MMP inhibitor, displaying greater than 93% inhibition for eight different MMPs (MMP-1, -2, -8, -9, -12, -13, -14, and -20) and greater than 73% for MMP-7 at 10 uM.
    CM-352 (200 nM) delayed fibrinolysis front velocity induced by tPA (76% reduction) and exhibited higher antifibrinolytic activity than tranexamic acid (TXA) in whole blood.
    CM-352 reduced blood loss during liver hepatectomy in vivo.

    Physicochemical Properties

    M.Wt 487.57
    Formula C24H29N3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-hydroxy-2-((4-(4-(methylcarbamoyl)phenoxy)phenyl)sulfonyl)-8-azaspiro[4.5]decane-2-carboxamide

    References

    1. Orbe J, et al. J Med Chem. 2015 Apr 9;58(7):2941-57.

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