| Cat. No. |
Product Name |
Information |
| PC-35033 |
BI-4394
MMP-13 inhibitor
|
BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM). |
| PC-63509 |
MMPI-1154
MMP-2 inhibitor
|
MMPI-1154 is a small molecule MMP-2 inhibitor with IC50 of 10/6.6/13/1.8 uM for MMP1/2/9/13, respectively. |
| PC-42999 |
SB-3CT
MMP2/9 inhibitor
|
SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM). |
| PC-63178 |
RO 28-2653
MMP inhibitor
|
RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM). |
| PC-62949 |
ADAMTS-5 inhibitor 15f
ADAMTS5 inhibitor
|
ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
| PC-62948 |
ADAMTS-5 inhibitor 8
ADAMTS5 inhibitor
|
ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
| PC-62947 |
Tanomastat
MMP inhibitor
|
Tanomastat (BAY 129566) is a potent,orally available, non-peptidic inhibitor of MMP-2, MMP-3 and MMP-9 with 11, 143 and 301 nM, respectively. |
| PC-62946 |
CGS 27023A
MMP inhibitor
|
CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9. |
| PC-62945 |
Cipemastat
MMP inhibitor
|
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9). |
| PC-62944 |
Prinomastat
MMP inhibitor
|
Prinomastat (AG3340) is a potent, selective MMP inhibitor with pM affinities for inhibiting gelatinases (MMP-2 and -9, Ki=50-150 pM), MMP-14 and MMP-13. |
| PC-62943 |
MMP13-IN-24f
MMP-13 inhibitor
|
MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM). |
| PC-62942 |
MMP13-IN-31f
|
MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM. |
