Chemical Structure : RO 28-2653
CAS No.:
261956-22-3
RO 28-2653
(RO 282653)
Catalog No.: PC-63178Not For Human Use, Lab Use Only.
RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).
RO 28-2653 reduces the growth of tumors induced by the inoculation of different cell lines producing MMPs and inhibits the tumor-promoting effect of fibroblasts on breast adenocarcinoma cells.
RO 28-2653 reduces tumor growth and prolongs survival in a prostate cancer standard rat model.
Physicochemical Properties
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M.Wt
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485.5
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Formula
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C26H23N5O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-[1,1'-Biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione
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References
1. Abramjuk C, et al. Anticancer Drugs. 2005 Sep;16(8):855-61.
2. Maquoi E, et al. Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4038-47.
3. Mangoldt D, et al. Apoptosis. 2002 Jun;7(3):217-20.
4. Lein M, et al. Oncogene. 2002 Mar 27;21(13):2089-96.
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