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Chemical Structure : Cipemastat
Catalog No.: PC-62945Not For Human Use, Lab Use Only.
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9).
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Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9).
Cipemastat (Ro 32-3555) inhibits human collagenases 1, 2 and 3 (Ki of 3.0, 4.4 and 3.4 nM), and Ro 323555 is a selective inhibitor of collagenases over the related stromelysin 1, and gelatinases A and B (Ki of 527, 154 and 59 nM).
Cipemastat (Ro 32-3555) prevents cartilage breakdown both in vitro and in vivo.
| M.Wt | 436.553 | |
| Formula | C22H36N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lewis EJ, et al. Br J Pharmacol. 1997 Jun;121(3):540-6.
2. Whittaker M, et al. Chem Rev. 1999 Sep 8;99(9):2735-76.
3. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8.
4. Brewster M, et al. Arthritis Rheum. 1998 Sep;41(9):1639-44.
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