Chemical Structure : Cipemastat
CAS No.:
190648-49-8
Cipemastat
(Ro 32-3555, Ro32-3555)
Catalog No.: PC-62945Not For Human Use, Lab Use Only.
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9).
Cipemastat (Ro 32-3555) inhibits human collagenases 1, 2 and 3 (Ki of 3.0, 4.4 and 3.4 nM), and Ro 323555 is a selective inhibitor of collagenases over the related stromelysin 1, and gelatinases A and B (Ki of 527, 154 and 59 nM).
Cipemastat (Ro 32-3555) prevents cartilage breakdown both in vitro and in vivo.
Physicochemical Properties
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M.Wt
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436.553
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Formula
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C22H36N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(αR,βR)-β-(CyclopentylMethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-triMethyl-2,5-dioxo-1-iMidazolidinyl)Methyl]-1-piperidinebutanaMide
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References
1. Lewis EJ, et al. Br J Pharmacol. 1997 Jun;121(3):540-6.
2. Whittaker M, et al. Chem Rev. 1999 Sep 8;99(9):2735-76.
3. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8.
4. Brewster M, et al. Arthritis Rheum. 1998 Sep;41(9):1639-44.
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