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Chemical Structure : MMP13-IN-24f
Catalog No.: PC-62943Not For Human Use, Lab Use Only.
MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM).
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MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM).
MMP13-IN-24f significantly reduces proteoglycan release in rat model of MMP-13-induced cartilage degradation at 30 mg/kg (75% inhibition) and at 10 mg/kg (40% inhibition).
| M.Wt | 510.62 | |
| Formula | C23H30N2O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Monovich LG, et al. J Med Chem. 2009 Jun 11;52(11):3523-38.
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