SB-3CT |CAS:292605-14-2 Probechem Biochemicals

Chemical Structure : SB-3CT

CAS No.: 292605-14-2

SB-3CT (SB 3CT;SB3CT)

Catalog No.: PC-42999Not For Human Use, Lab Use Only.

SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM).

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Biological Activity

SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM).
SB-3CT also poorly inhibits the closely related zinc-dependent metalloprotease ADAM-17.
SB-3CT demonstrates antitumor activity in a mouse model of T-cell lymphoma and shows significant reduction in the growth and number of experimental liver metastases and to an increase in survival.
SB-3CT blocks MMP-9 activity, including MMP-9-mediated laminin cleavage, thus rescuing neurons from apoptosis in transient focal cerebral ischemia

Physicochemical Properties

M.Wt	306.3999
Formula	C15H14O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-

References

1. Krüger A, et al. Cancer Res. 2005 May 1;65(9):3523-6.

2. Brown S, et al. Potent and Selective Mechanism-Based Inhibition of Gelatinases. J. Am. Chem. Soc., 2000, 122 (28), pp 6799-6800.

3. Gu Z, et al. J Neurosci. 2005 Jul 6;25(27):6401-8.

4. Bonfil RD, et al. Int J Cancer. 2006 Jun 1;118(11):2721-6.

SB-3CT (SB 3CT;SB3CT)

Biological Activity

Physicochemical Properties

References

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