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ADAMTS-5 inhibitor 8

Chemical Structure : ADAMTS-5 inhibitor 8

CAS No.: 1394122-20-3

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ADAMTS-5 inhibitor 8

Catalog No.: PC-62948Not For Human Use, Lab Use Only.

ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE.
    ADAMTS-5 inhibitor 8 inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.

    Physicochemical Properties

    M.Wt 624.841
    Formula C29H36N8O2S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-((1-(4-(but-3-en-1-ylamino)-6-(((2-(thiophen-2-yl)thiazol-4-yl)methyl)amino)-1,3,5-triazin-2-yl)pyrrolidin-2-yl)methyl)-4-propylbenzenesulfonamide

    References

    1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79.

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