| Cat. No. |
Product Name |
Information |
| PC-62948 |
ADAMTS-5 inhibitor 8
ADAMTS5 inhibitor
|
ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
| PC-62947 |
Tanomastat
MMP inhibitor
|
Tanomastat (BAY 129566) is a potent,orally available, non-peptidic inhibitor of MMP-2, MMP-3 and MMP-9 with 11, 143 and 301 nM, respectively. |
| PC-62946 |
CGS 27023A
MMP inhibitor
|
CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9. |
| PC-62945 |
Cipemastat
MMP inhibitor
|
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9). |
| PC-62944 |
Prinomastat
MMP inhibitor
|
Prinomastat (AG3340, KB-R9896) is a potent, selective MMP inhibitor with pM affinities for inhibiting gelatinases (MMP-2 and -9, Ki=50-150 pM), MMP-14 and MMP-13. |
| PC-62943 |
MMP13-IN-24f
MMP-13 inhibitor
|
MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM). |
| PC-62942 |
MMP13-IN-31f
|
MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM. |
| PC-62941 |
DB04760
MMP-13 inhibitor
|
DB04760 is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs. |
| PC-62940 |
CL-82198
MMP-13 inhibitor
|
CL-82198 is a potent, selective inhibitor of MMP-13 (89% inhibition at 10 ug/mL), displays no activity at MMP-1, MMP-9 and TACE, significantly reduces the migration of LS174 cells by 55% at 10 uM.. |
| PC-62939 |
CL-82198 hydrochloride
MMP-13 inhibitor
|
CL-82198 is a potent, selective inhibitor of MMP-13 (89% inhibition at 10 ug/mL), displays no activity at MMP-1, MMP-9 and TACE, significantly reduces the migration of LS174 cells by 55% at 10 uM.. |
| PC-62731 |
ML104
MMP-2 inhibitor
|
ML104 is a "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9. |
| PC-62402 |
UK 356618
MMP3 inhibitor
|
UK 356618 (UK356618) is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM). |
