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MMP13-IN-31f

Chemical Structure : MMP13-IN-31f

CAS No.: 935759-55-0

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MMP13-IN-31f

Catalog No.: PC-62942Not For Human Use, Lab Use Only.

MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM.
MMP13-IN-31f exhibits 5,000-fold selectivity for MMP-13 over MMP-2, >1,500-fold selectivity over MMP-10, and >27,000-fold selectivity over MMP-1, 3, 7, 8, 9, 14, and TACE.
MMP13-IN-31f prevents IL-1/OSM induced in vitro degradation of BNC (70.8% inhibition of cartilage degradation at 1 µM).

Physicochemical Properties

M.Wt 506.512
Formula C24H19FN6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide

References

1. Nara H, et al. J Med Chem. 2017 Jan 26;60(2):608-626.

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