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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-UK 356618
UK 356618

Chemical Structure : UK 356618

CAS No.: 230961-08-7

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UK 356618 (UK356618)

Catalog No.: PC-62402Not For Human Use, Lab Use Only.

UK 356618 is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UK 356618 (UK356618) is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM); significantly reduces hemorrhagic transformation and improves functional outcomes in hyperglycemic stroke.

Physicochemical Properties

M.Wt 557.72
Formula C34H43N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide

References

1. Fray MJ, et al. Bioorg Med Chem Lett. 2001 Feb 26;11(4):571-4.

2. Hafez S, et al. Stroke. 2016 Mar;47(3):843-51.

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