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Chemical Structure : ML104
Catalog No.: PC-62731Not For Human Use, Lab Use Only.
ML104 is a "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
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ML104 is a "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
ML104 affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1).
ML104 also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.
| M.Wt | 441.712 | |
| Formula | C13H14ClNO8P2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505.
2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840.
3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68.
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