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Chemical Structure : proMMP9-IN-3c
Catalog No.: PC-61898Not For Human Use, Lab Use Only.
proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM.
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proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM.
proMMP9-IN-3c disrupts MMP-9 homodimerization, prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in dissociation of EGFR.
proMMP9-IN-3c decreases phosphorylation of Src and its downstream target proteins FAK and paxillin in cancer cells.
proMMP9-IN-3c blocks cancer cell invasion of the basement membrane and reduces angiogenesis at 500 nM.
| M.Wt | 361.435 | |
| Formula | C18H20FN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alford VM, et al. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803.
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