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proMMP9-IN-3c

Chemical Structure : proMMP9-IN-3c

CAS No.: 2138321-18-1

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proMMP9-IN-3c

Catalog No.: PC-61898Not For Human Use, Lab Use Only.

proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM.
proMMP9-IN-3c disrupts MMP-9 homodimerization, prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in dissociation of EGFR.
proMMP9-IN-3c decreases phosphorylation of Src and its downstream target proteins FAK and paxillin in cancer cells.
proMMP9-IN-3c blocks cancer cell invasion of the basement membrane and reduces angiogenesis at 500 nM.

Physicochemical Properties

M.Wt 361.435
Formula C18H20FN3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-fluorophenyl)-4-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-ylthio)butanamide

References

1. Alford VM, et al. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803.

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