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PF-152

Chemical Structure : PF-152

CAS No.: 1112169-64-8

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PF-152 (PF152)

Catalog No.: PC-61148Not For Human Use, Lab Use Only.

PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).
    PF-152 also displays high selectivity against a panel of 14 matrix metalloproteinases, TACE, ADAMTS-4 and ADAMTS-5.
    PF-152 suppresses MMP-13 mediated cartilage degradation in vivo, shows potential for treatment of oteoarthritis.

    Physicochemical Properties

    M.Wt 473.465
    Formula C21H24FN7O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide

    References

    1. Ruminski PG, et al. J Med Chem. 2016 Jan 14;59(1):313-27.

    2. Settle S, et al. Arthritis Rheum. 2010 Oct;62(10):3006-15.

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