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Chemical Structure : DB04760
CAS No.: 544678-85-5
Catalog No.: PC-62941Not For Human Use, Lab Use Only.
DB04760 is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DB04760 is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs.
DB04760 does not interact with the catalytic zinc but bind deeply in the S1' pocket of MMP-13.
DB04760 significantly rescues axon regeneration and axon debris clearance, greatly reduces neurotoxicity associated with paclitaxel treatment in larval and adult zebrafish.
| M.Wt | 410.425 | |
| Formula | C22H20F2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide |
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1. Engel CK, et al. Chem Biol. 2005 Feb;12(2):181-9.
2. Lisse TS, et al. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2189-98.
3. Waldron AL, et al. J Diabetes Complications. 2018 Mar;32(3):249-257.
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