| Cat. No. |
Product Name |
Information |
| PC-61148 |
PF-152
MMP13 inhibitor
|
PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM). |
| PC-60981 |
BK-1361
ADAM8 inhibitor
|
BK-1361 (BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM. |
| PC-60174 |
ND-378
MMP-2 inhibitor
|
ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM. |
| PC-45629 |
NAMI-A
MMP-2/9 inhibitor
|
A ruthenium anticancer agent that has a selective effect on lung metastases of solid metastasizing tumors. |
| PC-42562 |
CTS-1027
MMP inhibitor
|
CTS-1027 (RS-130830) is a potent, selective, broad-spectrum MMP inhibitor with Ki of <9 nM for MMP2, 3, 8, 9, 12, 13 and 14, but not MMP1 and 7. |
| PC-42086 |
TAPI-2
ADAM17 inhibitor
|
TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE, ADAM17), ADAMs, and other MMPs, inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 uM, respectively. |
| PC-42904 |
Marimastat
MMP inhibitor
|
Marimastat (BB-2516, TA-2516) is a potent, broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively. |
| PC-25877 |
JG26
ADAM17 inhibitor
|
JG26 is a potent, selective ADAM17 inhibitor with IC50 of IC50 of 1.9 nM, weakly inhibits ADAM-10 and MMP-2 (IC50=150 and 240 nM), does not inhibit MMP-1/9/14. |
| PC-25875 |
KP-457
ADAM17 inhibitor
|
KP-457 is a potent, selective ADAM17 inhibitor with IC50 of 11.1 nM, >50 times more selective for ADAM17 than for other MMPs and ADAM10. |
| PC-25874 |
INCB3619
ADAM10/ADAM17 inhibitor
|
INCB3619 (INCB-3619) is a potent, selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. |
| PC-25431 |
ADAM17 inhibitor 2155-17
ADAM17 inhibitor
|
ADAM17 inhibitor 2155-17 is a specific small molecule ADAM17 inhibitor with IC50 of 4.3 uM, with no activity against MMP2, MMP8, MMP9 ,MMP14, and ADAM10 (IC50>100 uM). |
| PC-24822 |
FLF-15
ADAM17 inhibitor
|
FLF-15 is a potent, selective ADAM17 inhibitor with IC50 of 10.43 nM, selectively inhibits its IL-6R cleavage activity, inhibits HCC migration and invasion in vitro and in vivo. |
