ND-378 |CAS:1807453-72-0 Probechem Biochemicals

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Chemical Structure : ND-378

ND-378 (ND378;ND 378)

Catalog No.: PC-60174Not For Human Use, Lab Use Only.

ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM.
ND-378 does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM).
ND-378 can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice.

Physicochemical Properties

M.Wt	377.473
Formula	C18H19NO4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)benzyl)acetamide

References

1. Gao M, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487.

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ND-378 (ND378;ND 378)

Biological Activity

Physicochemical Properties

References

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