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ND-336

Chemical Structure : ND-336

CAS No.: 1807453-83-3

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ND-336 (ND336;ND 336)

Catalog No.: PC-70316Not For Human Use, Lab Use Only.

ND-336 (ND336) is a potent, selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ND-336 (ND336) is a potent, selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively.
ND-336 has minimal effect on other MMPs.
ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition.

Physicochemical Properties

M.Wt 371.9
Formula C16H17NO3S2 • HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenyl)methanamine

References

1. Gao M, et al. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31.

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