Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM.
Trimeric MMP-9 inhibitor 7 displays 450-fold selectivity for MMP-9 over MMP-1, and 500-fold selectivity for MMP-9 trimers over monomers.
Trimeric MMP-9 inhibitor 7 reduces invasion in three glioma cell lines expressing MMP-9 at different levels.
Trimeric MMP-9 inhibitor 7 amplifies leukocyte influxes towards lipopolysaccharide-induced inflammation in a mouse model for chemotaxis.
