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Chemical Structure : Trimeric MMP-9 inhibitor 7
Catalog No.: PC-20535Not For Human Use, Lab Use Only.
Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM.
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Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM.
Trimeric MMP-9 inhibitor 7 displays 450-fold selectivity for MMP-9 over MMP-1, and 500-fold selectivity for MMP-9 trimers over monomers.
Trimeric MMP-9 inhibitor 7 reduces invasion in three glioma cell lines expressing MMP-9 at different levels.
Trimeric MMP-9 inhibitor 7 amplifies leukocyte influxes towards lipopolysaccharide-induced inflammation in a mouse model for chemotaxis.
| M.Wt | 883.04 | |
| Formula | C46H50N4O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Elisa Nuti, et al. ACS Med Chem Lett. 2017 Feb 7;8(3):293-298.
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