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Chemical Structure : MMP118
Catalog No.: PC-20538Not For Human Use, Lab Use Only.
MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively.
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MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively.
MMP118 has excellent selectivity over other human MMPs (MMP2, MMP3, MMP9).
MMP118 (5 mg, p.o. bid) exhibited the minimum efficacious effect against the rhMMP-12 induced mouse lung inflammation model.
| M.Wt | 430.49 | |
| Formula | C20H18N2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuchuan Wu, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43.
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