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MMP118

Chemical Structure : MMP118

CAS No.: 1080637-90-6

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MMP118 (MMP 118)

Catalog No.: PC-20538Not For Human Use, Lab Use Only.

MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively.
    MMP118 has excellent selectivity over other human MMPs (MMP2, MMP3, MMP9).
    MMP118 (5 mg, p.o. bid) exhibited the minimum efficacious effect against the rhMMP-12 induced mouse lung inflammation model.

    Physicochemical Properties

    M.Wt 430.49
    Formula C20H18N2O5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    CC(C)[C@@H](C(O)=O)NS(=O)(C1=CC=C2C(OC3=CC=C(C4=NC=CS4)C=C23)=C1)=O

    References

    1. Yuchuan Wu, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43.

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