ARP100 | MMP2 inhibitor | Probechem Biochemicals

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Chemical Structure : ARP100

CAS No.: 704888-90-4

ARP100 (ARP-100)

Catalog No.: PC-20588Not For Human Use, Lab Use Only.

ARP100 (ARP-100) is a potent, selective gelatinase A (MMP-2) inhibitor with IC50 of 12 nM, weakly inhibits MMP-9 (IC50=200 nM) and >300-fold selectivity over MMP1/3/7.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ARP100 (ARP-100) is a potent, selective gelatinase A (MMP-2) inhibitor with IC50 of 12 nM, weakly inhibits MMP-9 (IC50=200 nM) and >300-fold selectivity over MMP1/3/7.
ARP100 (50 nM) inhibits HT1080 sarcoma cells growth on matrigel.
ARP100 significantly reduces secretion of TGF-β1 in metastatic Y79 cell line.

Physicochemical Properties

M.Wt	364.42
Formula	C17H20N2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C

References

1. Huang YH, et al. Sci Rep. 2021 Jun 9;11(1):12171.

2. Webb AH, et al. BMC Cancer. 2017 Jun 20;17(1):434.

3. Armando Rossello, et al. Bioorg Med Chem. 2004 May 1;12(9):2441-50.

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ARP100 (ARP-100)

Biological Activity

Physicochemical Properties

References

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