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Chemical Structure : ARP100
CAS No.: 704888-90-4
Catalog No.: PC-20588Not For Human Use, Lab Use Only.
ARP100 (ARP-100) is a potent, selective gelatinase A (MMP-2) inhibitor with IC50 of 12 nM, weakly inhibits MMP-9 (IC50=200 nM) and >300-fold selectivity over MMP1/3/7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 100 mg | $698 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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ARP100 (ARP-100) is a potent, selective gelatinase A (MMP-2) inhibitor with IC50 of 12 nM, weakly inhibits MMP-9 (IC50=200 nM) and >300-fold selectivity over MMP1/3/7.
ARP100 (50 nM) inhibits HT1080 sarcoma cells growth on matrigel.
ARP100 significantly reduces secretion of TGF-β1 in metastatic Y79 cell line.
| M.Wt | 364.42 | |
| Formula | C17H20N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C |
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1. Huang YH, et al. Sci Rep. 2021 Jun 9;11(1):12171.
2. Webb AH, et al. BMC Cancer. 2017 Jun 20;17(1):434.
3. Armando Rossello, et al. Bioorg Med Chem. 2004 May 1;12(9):2441-50.
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