Chemical Structure : MMP-12 inhibitor 9
CAS No.:
868368-30-3
MMP-12 inhibitor 9
(MMP-12i)
Catalog No.: PC-20537Not For Human Use, Lab Use Only.
MMP-12 inhibitor 9 is a potent selective MMP-12 inhibitor with IC50 of 177 nM, displays anti-inflammatory activity in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MMP-12 inhibitor 9 is a potent selective MMP-12 inhibitor with IC50 of 177 nM, displays anti-inflammatory activity in vitro and in vivo.
MMP-12 inhibitor 9 is poorly potent against MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, and MMP-13 (IC50>50 uM), displays slightly better inhibitory activity towards MMP-2, MMP-8, and MMP-14 (IC50=2-50 uM).
MMP-12 inhibitor 9 displayed significantly lower lipopolysaccharide- (LPS-) induced lethality compared to vehicle treated controls C57BL/6 mice.
C57BL/6 mice attenuated LPS-induced decrease in tight junction permeability of primary choroid plexus epithelial cells in vitro.
Physicochemical Properties
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M.Wt
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411.46
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Formula
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C26H21NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=C(O)C(C=C(C)O1)=O)NCC2=CC=C(C3=CC=C(C4=CC=CC=C4)C=C3)C=C2
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References
1. Aerts J, et al. Mediators Inflamm. 2015;2015:510679.
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