ADAMTS-5 inhibitor 12

Chemical Structure : ADAMTS-5 inhibitor 12

CAS No.: 929634-33-3

Catalog No.: PC-23033Not For Human Use, Lab Use Only.

ADAMTS-5 inhibitor 12 is a potent selective ADAMTS-5 (aggrecanase-2) inhibitor with IC50 of 1.1 uM, >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$358	In stock
50 mg	$558	In stock
100 mg		Get quote

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Biological Activity

ADAMTS-5 inhibitor 12 is a potent selective ADAMTS-5 (aggrecanase-2) inhibitor with IC50 of 1.1 uM, >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

Physicochemical Properties

M.Wt	449.91
Formula	C16H11ClF3N3OS3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-((4-Chlorobenzyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one

References

1. Gilbert AM, et al. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92.

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