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CID 3117694

Chemical Structure : CID 3117694

CAS No.: 331636-31-8

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CID 3117694 (CID3117694)

Catalog No.: PC-20621Not For Human Use, Lab Use Only.

CID 3117694 is a selective, non-competitive inhibitor of ADAM10 with IC50 of 1.1 uM, does not inhibit ADAM17.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CID 3117694 is a selective, non-competitive inhibitor of ADAM10 with IC50 of 1.1 uM, does not inhibit ADAM17.
CID 3117694 inhibits ADAM10 via a non-zinc-binding mechanism.
CID 3117694 displays no activity against a panel of metzincins (MMP1/2/8/9/10/13/14, Meprin α and Meprin β).
CID 3117694 exhibits dose-dependent inhibition of shedding of HER2 from the surface of BT474 cells with IC50 of 30 uM, as well as CXCL16 and syndecan-4 shedding.
CID 3117694 inhibits both CCL2-induced migration of peripheral blood mononuclear cells (PBMC) and IL-8-induced migration of primary human neutrophils.

Physicochemical Properties

M.Wt 361.78
Formula C17H16ClN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NC1=CC=C(C)C(Cl)=C1)C(NNC(C2=CC=CC(OC)=C2)=O)=O

References

1. Franck Madoux, et al. Sci Rep. 2016; 6: 11.

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