(R)-YNT-3708

Chemical Structure : (R)-YNT-3708

Catalog No.: PC-20559Not For Human Use, Lab Use Only.

(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).

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Biological Activity

(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).
(R)-YNT-3708 (60 mg/kg, s.c.) exhibited antinociceptive and reinforcing effects through the activation of OX1R in mice.

Physicochemical Properties

M.Wt	640.76
Formula	C35H36N4O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=NC=C1)/C=C/C2=CC=C(OC)C(S(=O)(NC3=CC=C4CCC[C@@H](N(C)C(CC5=CC=CC(OC)=C5)=O)C4=C3)=O)=C2

References

1. Keita Iio, et al. J Med Chem. 2023 Apr 12. doi: 10.1021/acs.jmedchem.2c01773.

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(R)-YNT-3708

Biological Activity

Physicochemical Properties

References

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