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Chemical Structure : (R)-YNT-3708
Catalog No.: PC-20559Not For Human Use, Lab Use Only.
(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).
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(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).
(R)-YNT-3708 (60 mg/kg, s.c.) exhibited antinociceptive and reinforcing effects through the activation of OX1R in mice.
| M.Wt | 640.76 | |
| Formula | C35H36N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Keita Iio, et al. J Med Chem. 2023 Apr 12. doi: 10.1021/acs.jmedchem.2c01773.
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