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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Orexin Receptor-(R)-YNT-3708
(R)-YNT-3708

Chemical Structure : (R)-YNT-3708

CAS No.: 2923137-94-2

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(R)-YNT-3708 ((R)-YNT3708)

Catalog No.: PC-20559Not For Human Use, Lab Use Only.

(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).
    (R)-YNT-3708 (60 mg/kg, s.c.) exhibited antinociceptive and reinforcing effects through the activation of OX1R in mice.

    Physicochemical Properties

    M.Wt 640.76
    Formula C35H36N4O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R,E)-3-(4-methoxy-3-(N-(8-(2-(3-methoxyphenyl)-N-methylacetamido)-5,6,7,8-tetrahydronaphthalen-2-yl)sulfamoyl)phenyl)-N-(pyridin-4-yl)acrylamide

    References

    1. Keita Iio, et al. J Med Chem. 2023 Apr 12. doi: 10.1021/acs.jmedchem.2c01773.

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