| Cat. No. |
Product Name |
Information |
| PC-21740 |
CVN766
OX1R inhibitor
|
CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R. |
| PC-20563 |
RTOXA-43
Dual OX1R/OX2R agonist
|
RTOXA-43 is a potent, dual orexin receptor agonist with EC50 of 24 nM at both OX2R and OX1R. |
| PC-20559 |
(R)-YNT-3708
OX1R agonist
|
(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM). |
| PC-49188 |
OBPt-9
OXR1/2 potentiator
|
OBPt-9 is a potent, postivie allosteric potentiator of orexin receptor-mediated signaling, similarly potentiates the response of OXR1 and OXR2 to orexin A. |
| PC-38428 |
Vornorexant
Orexin Receptor inhibitor
|
Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 and 2 receptor antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively. |
| PC-38360 |
Firazorexton
OX2R agonist
|
Firazorexton (TAK-994) is a potent, selective, orally available and brain-penetrant agonist of orexin 2 receptor (OX2R) with EC50 of 19 nM against recombinant human OX2R, 700-fold selectivity against OX1R. |
| PC-73244 |
YNT-185
OX2R agonist
|
YNT-185 is a potent, selective orexin type-2 receptor (OX2R) agonist with EC50 of 28 nM, 100-fold selectivity over OX1R. |
| PC-72749 |
TAK-925
OX2R agonist
|
TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM). |
| PC-72582 |
OX2R agonist 1
OX2R agonist
|
OX2R agonist 1 is a potent, selective, small-molecule agonist of orexin receptor 2 (OX2R) with pEC50 of 8.28, >300-fold selectivity over OX1R. |
| PC-35934 |
Nag 26
OX2R agonist
|
Nag 26 (Orexin receptor agonist Nag26) is a potent, selective orexin/hypocretin receptor 2 (OX2R) agonist with EC50 of 23 nM, Emax=98%. |
| PC-42964 |
MK-3697
OX2R inhibitor
|
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM). |
| PC-61107 |
Seltorexant
OX2R inhibitor
|
Seltorexant (JNJ-42847922, MIN-202) is a potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively. |
