Vornorexant (TS-142, ORN0829)

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Chemical Structure : Vornorexant

CAS No.: 1517965-94-4

Catalog No.: PC-38428Not For Human Use, Lab Use Only.

Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 and 2 receptor antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.

Packing	Price	Stock
5 mg	$248	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 (OX1R) and 2 receptor (OX2R) antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.
Vornorexant (TS-142, ORN0829) exhibited potent sleep-promoting effects at a po dose of 1 mg/kg in a rat polysomnogram study.
Vornorexant (TS-142, ORN0829) is a viable candidate and is currently in clinical development for the treatment of insomnia.

Physicochemical Properties

M.Wt	447.474
Formula	C23H22FN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[(2S)-2-[[3-(5-Fluoro-2-pyridinyl)-1H-pyrazol-1-yl]methyl]dihydro-2H-1,3-oxazin-3(4H)-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

References

1. Futamura A, et al. Bioorg Med Chem. 2020 Jul 1;28(13):115489.

2. Uchiyama M, et al. Psychopharmacology (Berl). 2022 Mar 17.

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