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Chemical Structure : Vornorexant
Catalog No.: PC-38428Not For Human Use, Lab Use Only.
Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 and 2 receptor antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.
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Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 (OX1R) and 2 receptor (OX2R) antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.
Vornorexant (TS-142, ORN0829) exhibited potent sleep-promoting effects at a po dose of 1 mg/kg in a rat polysomnogram study.
Vornorexant (TS-142, ORN0829) is a viable candidate and is currently in clinical development for the treatment of insomnia.
| M.Wt | 447.474 | |
| Formula | C23H22FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Futamura A, et al. Bioorg Med Chem. 2020 Jul 1;28(13):115489.
2. Uchiyama M, et al. Psychopharmacology (Berl). 2022 Mar 17.
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