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Vornorexant

Chemical Structure : Vornorexant

CAS No.: 1517965-94-4

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Vornorexant (TS-142, ORN0829)

Catalog No.: PC-38428Not For Human Use, Lab Use Only.

Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 and 2 receptor antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 (OX1R) and 2 receptor (OX2R) antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively.
    Vornorexant (TS-142, ORN0829) exhibited potent sleep-promoting effects at a po dose of 1 mg/kg in a rat polysomnogram study.
    Vornorexant (TS-142, ORN0829) is a viable candidate and is currently in clinical development for the treatment of insomnia.

    Physicochemical Properties

    M.Wt 447.474
    Formula C23H22FN7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(2S)-2-[[3-(5-Fluoro-2-pyridinyl)-1H-pyrazol-1-yl]methyl]dihydro-2H-1,3-oxazin-3(4H)-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

    References

    1. Futamura A, et al. Bioorg Med Chem. 2020 Jul 1;28(13):115489.

    2. Uchiyama M, et al. Psychopharmacology (Berl). 2022 Mar 17.

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