Chemical Structure : JNJ-61393215
CAS No.:
1637681-55-0
JNJ-61393215
(Tebideutorexant, JNJ 61393215)
Catalog No.: PC-21917Not For Human Use, Lab Use Only.
JNJ-61393215 (Tebideutorexant) is a potent, selective orexin-1 receptor (OX1R) antagonist with pKi values of 8.17 and 8.13 for human OX1R and rat OX1R, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ-61393215 (Tebideutorexant) is a potent, selective orexin-1 receptor (OX1R) antagonist with pKi values of 8.17 and 8.13 for human OX1R and rat OX1R, respectively.
JNJ-61393215 displays >100 -fold binding affinity for human OX1R compared with human OX2R (pKi=6.12), also shows no significant affinity for a panel of other receptors, ion channels, transporters, and kinases (Eurofins).
JNJ-61393215 selectively promotes REM sleep in OX2R-knockout (KO) mice, attenuates CO2-induced fear and cardiovascular response in rats.
Physicochemical Properties
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M.Wt
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460.43
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Formula
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C23H16D2F4N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl-3,3-d2)methanone
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References
1. Salvadore G, et al. Transl Psychiatry. 2020 Sep 7;10(1):308.
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