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RTOXA-43

Chemical Structure : RTOXA-43

CAS No.: 2832067-72-6

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RTOXA-43 (RTOXA43)

Catalog No.: PC-20563Not For Human Use, Lab Use Only.

RTOXA-43 is a potent, dual orexin receptor agonist with EC50 of 24 nM at both OX2R and OX1R.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RTOXA-43 is a potent, dual orexin receptor agonist with EC50 of 24 nM at both OX2R and OX1R.
RTOXA-43 (40 mg/kg, i.p.) increased time awake, decreased time asleep and increased sleep/wake consolidation when measured using continuous EEG/EMG recordings in 12-month old mice.

Physicochemical Properties

M.Wt 663.79
Formula C37H37N5O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4'-methoxy-N-methyl-3'-(N-(3-((2-(3-methylbenzamido)ethyl)amino)phenyl)sulfamoyl)-N-(pyridin-4-ylmethyl)-[1,1'-biphenyl]-3-carboxamide

References

1. Dehui Zhang, et al. J Med Chem. 2021 Jun 24;64(12):8806-8825.

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