Chemical Structure : Firazorexton
CAS No.: 2274802-95-6
Catalog No.: PC-38360Not For Human Use, Lab Use Only.
Firazorexton (TAK-994) is a potent, selective, orally available and brain-penetrant agonist of orexin 2 receptor (OX2R) with EC50 of 19 nM against recombinant human OX2R, 700-fold selectivity against OX1R.
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M.Wt | 470.507 | |
Formula | C22H25F3N2O4S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-((2S,3S)-1-(2-hydroxy-2-methylpropanoyl)-2-((2,3',5'-trifluoro-[1,1'-biphenyl]-3-yl)methyl)pyrrolidin-3-yl)methanesulfonamide |
1. Takashi Ishikawa, et al. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204.
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