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Chemical Structure : CVN766
CAS No.: 1803557-42-7
Catalog No.: PC-21740Not For Human Use, Lab Use Only.
CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.
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CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.
CVN766 displays slow off rate binding kinetics leading to an extended receptor occupancy in rats.
CVN766also demonstrates high brain permeability and a pharmacokinetic and safety profile suitable for clinical studies.
| M.Wt | 446.44 | |
| Formula | C20H21F3N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((1S,2S)-2-((3-ethyl-5-(trifluoromethyl)pyrazin-2-yl)amino)cyclopentyl)-3-(2H-1,2,3-triazol-2-yl)picolinamide |
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1. Angela Glen, et al. Bioorg Med Chem Lett. 2024 Jan 29:129629.
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