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CVN766

Chemical Structure : CVN766

CAS No.: 1803557-42-7

CVN766 (CVN 766, CVN-766)

Catalog No.: PC-21740Not For Human Use, Lab Use Only.

CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.

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Purity & Documentation Purity: 97.8% (HPLC) Select Batch:

Biological Activity

CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.
CVN766 displays slow off rate binding kinetics leading to an extended receptor occupancy in rats.
CVN766also demonstrates high brain permeability and a pharmacokinetic and safety profile suitable for clinical studies.

Physicochemical Properties

M.Wt 446.44
Formula C20H21F3N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((1S,2S)-2-((3-ethyl-5-(trifluoromethyl)pyrazin-2-yl)amino)cyclopentyl)-3-(2H-1,2,3-triazol-2-yl)picolinamide

References

1. Angela Glen, et al. Bioorg Med Chem Lett. 2024 Jan 29:129629.

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