Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Orexin Receptor-CVN766
CVN766

Chemical Structure : CVN766

CAS No.: 1803557-42-7

CVN766 (CVN 766, CVN-766)

Catalog No.: PC-21740Not For Human Use, Lab Use Only.

CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.

Packing Price Stock Quantity
1 mg $158 In stock
5 mg $398 In stock
10 mg $598 In stock
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: 97.8% (HPLC) Select Batch:

Biological Activity

CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.
CVN766 displays slow off rate binding kinetics leading to an extended receptor occupancy in rats.
CVN766also demonstrates high brain permeability and a pharmacokinetic and safety profile suitable for clinical studies.

Physicochemical Properties

M.Wt 446.44
Formula C20H21F3N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((1S,2S)-2-((3-ethyl-5-(trifluoromethyl)pyrazin-2-yl)amino)cyclopentyl)-3-(2H-1,2,3-triazol-2-yl)picolinamide

References

1. Angela Glen, et al. Bioorg Med Chem Lett. 2024 Jan 29:129629.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: