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Chemical Structure : OX-201
Catalog No.: PC-22566Not For Human Use, Lab Use Only.
OX-201 is a potent, selective, BBB-penetrable orexin receptor 2 (OX2R) agonist with EC50 of 8.0 nM in calcium mobilization assay in hOX2R/CHO-K1 cells.
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OX-201 is a potent, selective, BBB-penetrable orexin receptor 2 (OX2R) agonist with EC50 of 8.0 nM in calcium mobilization assay in hOX2R/CHO-K1 cells.
OX-201 displays 1000-fold selectivity for OX2R over OX1R.
OX-201 at 10 μM does not show >50% inhibition or stimulation for 102 tested enzymes, receptors, or ion channels, except cannabinoid CB1 receptor (51% inhibition) and progesterone receptor B (53% inhibition).
OX-201 produced wake-promoting effects via OX2R activation in mice and rats.
OX-201 activated inspiratory neurons in the pre-Bötzinger complex in rat medullary slices.
OX-201 increased burst activity in rat isolated brainstem−spinal cord preparations.
OX-201 (3 mg/kg, i.v.) significantly increased burst frequency of the diaphragm in anesthetized rats.
| M.Wt | 506.49 | |
| Formula | C22H23F5N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamada R, et al. PLoS One. 2024 Jun 25;19(6):e0306099.
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