Chemical Structure : OX-201
CAS No.:
2460722-03-4
OX-201
(OX201)
Catalog No.: PC-22566Not For Human Use, Lab Use Only.
OX-201 is a potent, selective, BBB-penetrable orexin receptor 2 (OX2R) agonist with EC50 of 8.0 nM in calcium mobilization assay in hOX2R/CHO-K1 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
OX-201 is a potent, selective, BBB-penetrable orexin receptor 2 (OX2R) agonist with EC50 of 8.0 nM in calcium mobilization assay in hOX2R/CHO-K1 cells.
OX-201 displays 1000-fold selectivity for OX2R over OX1R.
OX-201 at 10 μM does not show >50% inhibition or stimulation for 102 tested enzymes, receptors, or ion channels, except cannabinoid CB1 receptor (51% inhibition) and progesterone receptor B (53% inhibition).
OX-201 produced wake-promoting effects via OX2R activation in mice and rats.
OX-201 activated inspiratory neurons in the pre-Bötzinger complex in rat medullary slices.
OX-201 increased burst activity in rat isolated brainstem−spinal cord preparations.
OX-201 (3 mg/kg, i.v.) significantly increased burst frequency of the diaphragm in anesthetized rats.
Physicochemical Properties
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M.Wt
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506.49
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Formula
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C22H23F5N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((2S,3R)-4,4-difluoro-1-(2-hydroxy-2-methylpropanoyl)-2-((2,3',5'-trifluoro-[1,1'-biphenyl]-3-yl)methyl)pyrrolidin-3-yl)methanesulfonamide
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References
1. Yamada R, et al. PLoS One. 2024 Jun 25;19(6):e0306099.
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