| Cat. No. |
Product Name |
Information |
| PC-42733 |
TCS 1102
Orexin receptor inhibitor
|
TCS 1102 is a potent and selective dual Orexin receptor antagonist with Ki of 0.2/3 nM for hOX2R/hOX1R respectively. |
| PC-42704 |
Almorexant
OX1R/OX2R antagonist
|
Almorexant (ACT-078573) is a potent, dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively. |
| PC-23032 |
TAK-861
OX2R agonist
|
TAK-861 is a potent, selective, orally available orexin receptor 2 (OX2R) agonist with EC50 of 2.5 nM, weakly activates OX1R (EC50=7.5 uM). |
| PC-22566 |
OX-201
OX2R agonist
|
OX-201 is a potent, selective, BBB-penetrable orexin receptor 2 (OX2R) agonist with EC50 of 8.0 nM in calcium mobilization assay in hOX2R/CHO-K1 cells. |
| PC-22236 |
DORA-12
Orexin receptor antagonist
|
DORA-12 (Dual orexin receptor antagonist 12) is a potent, dual orexin receptor (OX1R/OX2R) antagonist with Ki of 1.8/0.2 nM, respectively. |
| PC-21917 |
JNJ-61393215
OX1R inhibitor
|
JNJ-61393215 (Tebideutorexant) is a potent, selective orexin-1 receptor (OX1R) antagonist with pKi values of 8.17 and 8.13 for human OX1R and rat OX1R, respectively. |
| PC-21731 |
CVN45502
OX1R inhibitor
|
CVN45502 (CVN 45502) is a potent, orally bioavailable, highly selective orexin 1 receptor (Hcrtr1, OX1R) antagonist with binding affinity (pKi) of 7.86 (human Hcrtr1), significantly reduces feeding and body weight in diet-induced obese (DIO). |
| PC-21251 |
ACT-539313
OX1R inhibitor
|
Nivasorexant (ACT-539313) is a potent, selective and brain-penetrating orexin receptor type 1 receptor (OX1R) antagonist with Kb of 0.69 nM (human OX1R), 60-fold selective over OX2R. |
| PC-20561 |
Orexin Receptor agonist (R)-2
Dual OX1R/OX2R agonist
|
Orexin Receptor agonist (R)-2 is a potent, dual orexin receptor (OX1R and OX2R) agonist with EC50 of 13.5 nM for OX1R and 0.579 nM for OX2R. |
| PC-45972 |
SB-408124 hydrochloride
|
A potent, selective OX1 receptor antagonist with Ki of 57 nM (whole cell assay), and 27 nM (cell membrane-based SPA assay). |
| PC-42705 |
Almorexant hydrochloride
|
A dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively. |
