| Cat. No. |
Product Name |
Information |
| PC-45951 |
SB-408124
OX1R antagonist
|
SB-408124 is a potent, selective OX1 receptor (OX1R) antagonist with Ki of 57 nM (whole cell assay), and 27 nM (cell membrane-based SPA assay). |
| PC-42159 |
TCS-OX2-29
OX2R antagonist
|
TCS-OX2-29 is a potent, selective orexin-2 receptor (OX2R) antagonist with IC50 of 40 nM. |
| PC-42732 |
SB-674042
OX1R antagonist
|
SB-674042 is a potent, selective nonpeptide Orexin 1 receptor (OX1R) antagonist with Ki of 26.9 nM in the membrane SPA format, and Ki of 57 nM in the whole-cell assay. |
| PC-42733 |
TCS 1102
Orexin receptor inhibitor
|
TCS 1102 is a potent and selective dual Orexin receptor antagonist with Ki of 0.2/3 nM for hOX2R/hOX1R respectively. |
| PC-42704 |
Almorexant
OX1R/OX2R antagonist
|
Almorexant (ACT-078573) is a potent, dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively. |
| PC-25054 |
Fumiporexant
Orexin receptor antagonist
|
Fumiporexant is a potent, selective orexin receptor antagonist. |
| PC-25035 |
Cleminorexton
OX2R agonist
|
Cleminorexton is a potent, selective orexin-2 receptor (OX2R). |
| PC-24473 |
IDOR-1117-1680
Orexin receptor antagonist
|
IDOR-1117-1680 is a potent, dual orexin receptor antagonist with IC50 of 19 nM and 1.9 nM for hOX1R and hOX2R, respectively. |
| PC-24180 |
Rocavorexant
OX1R inhibitor
|
Rocavorexant is a potent, selective orexin-1 receptor (OX1R) inhibitor. |
| PC-22566 |
OX-201
OX2R agonist
|
OX-201 is a potent, selective, BBB-penetrable orexin receptor 2 (OX2R) agonist with EC50 of 8.0 nM in calcium mobilization assay in hOX2R/CHO-K1 cells. |
| PC-22236 |
DORA-12
Orexin receptor antagonist
|
DORA-12 (Dual orexin receptor antagonist 12) is a potent, dual orexin receptor (OX1R/OX2R) antagonist with Ki of 1.8/0.2 nM, respectively. |
| PC-21731 |
CVN45502
OX1R inhibitor
|
CVN45502 (CVN 45502) is a potent, orally bioavailable, highly selective orexin 1 receptor (Hcrtr1, OX1R) antagonist with binding affinity (pKi) of 7.86 (human Hcrtr1), significantly reduces feeding and body weight in diet-induced obese (DIO). |
