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SB-334867

Chemical Structure : SB-334867

CAS No.: 249889-64-3

SB-334867 (SB 334867A;SB334867;SB 334867)

Catalog No.: PC-42730Not For Human Use, Lab Use Only.

SB-334867 (SB 334867A) is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4.

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5 mg (Free Sample) $18 In stock
10 mg $98 In stock
25 mg $168 In stock
50 mg $268 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB-334867 (SB 334867A) is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4.
SB-334867 displays 50-fold selectivity over OX2 (pKb 5.7), >100-fold or selectivity over 5-HT2B, 5-HT2C and approximately 50 other molecular targets, in particular GPCRs and ion channels.
SB-334867 possesses CNS penetration, in vivo activity following ip dosing.

Physicochemical Properties

M.Wt 355.7784
Formula C17H14ClN5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, hydrochloride (1:1)

References

1. Smart D, et al. Br J Pharmacol. 2001 Mar;132(6):1179-82.

2. Porter RA, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10.

3. Rodgers RJ, et al. Eur J Neurosci. 2001 Apr;13(7):1444-52.

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