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Chemical Structure : TCS-OX2-29
CAS No.: 372523-75-6
Catalog No.: PC-42159Not For Human Use, Lab Use Only.
A potent, selective orexin-2 receptor (OX2R) antagonist with IC50 of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $112 | In stock | |
| 50 mg | $472 | In stock | |
| 100 mg | $792 | In stock |
Bulk size, bulk discount!
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A potent, selective orexin-2 receptor (OX2R) antagonist with IC50 of 40 nM; displays >250-fold selectivity for OX2 over OX1 and a panel of receptors, ion channels and transporters; blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.
| M.Wt | 397.5105 | |
| Formula | C23H31N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Butanone, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-, (2S)- |
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1. Hirose M, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9.
2. Urbańska A, et al. J Mol Neurosci. 2012 Jan;46(1):10-7.
3. Huang SC, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):522-9.
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