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TCS 1102

Chemical Structure : TCS 1102

CAS No.: 916141-36-1

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TCS 1102 (TCS1102;TCS-1102)

Catalog No.: PC-42733Not For Human Use, Lab Use Only.

TCS 1102 is a potent and selective dual Orexin receptor antagonist with Ki of 0.2/3 nM for hOX2R/hOX1R respectively.

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10 mg $88 In stock
25 mg $158 In stock
50 mg $258 In stock
100 mg $448 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TCS 1102 is a potent and selective dual Orexin receptor antagonist with Ki of 0.2/3 nM for hOX2R/hOX1R respectively.
TCS 1102 demonstrates excellent in vitro cell based activity, brain penetration, and low to moderate bioavailability in rats.

Physicochemical Properties

M.Wt 470.5859
Formula C27H26N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrrolidinecarboxamide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-, (2S)-

References

1. Bergman JM, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1425-30.

2. Khoo SY, et al. PLoS One. 2017 Mar 15;12(3):e0173967.

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