| Cat. No. |
Product Name |
Information |
| PC-21917 |
JNJ-61393215
OX1R inhibitor
|
JNJ-61393215 (Tebideutorexant) is a potent, selective orexin-1 receptor (OX1R) antagonist with pKi values of 8.17 and 8.13 for human OX1R and rat OX1R, respectively. |
| PC-21731 |
CVN45502
OX1R inhibitor
|
CVN45502 (CVN 45502) is a potent, orally bioavailable, highly selective orexin 1 receptor (Hcrtr1, OX1R) antagonist with binding affinity (pKi) of 7.86 (human Hcrtr1), significantly reduces feeding and body weight in diet-induced obese (DIO). |
| PC-21251 |
ACT-539313
OX1R inhibitor
|
Nivasorexant (ACT-539313) is a potent, selective and brain-penetrating orexin receptor type 1 receptor (OX1R) antagonist with Kb of 0.69 nM (human OX1R), 60-fold selective over OX2R. |
| PC-20563 |
RTOXA-43
Dual OX1R/OX2R agonist
|
RTOXA-43 is a potent, dual orexin receptor agonist with EC50 of 24 nM at both OX2R and OX1R. |
| PC-20561 |
Orexin Receptor agonist (R)-2
Dual OX1R/OX2R agonist
|
Orexin Receptor agonist (R)-2 is a potent, dual orexin receptor (OX1R and OX2R) agonist with EC50 of 13.5 nM for OX1R and 0.579 nM for OX2R. |
| PC-38428 |
Vornorexant
Orexin Receptor inhibitor
|
Vornorexant (TS-142, ORN0829) is a potent dual orexin 1 and 2 receptor antagonist with IC50 of 1.05 and 1.27 nM for hOX1R and hOX2R, resepctively. |
| PC-72582 |
OX2R agonist 1
OX2R agonist
|
OX2R agonist 1 is a potent, selective, small-molecule agonist of orexin receptor 2 (OX2R) with pEC50 of 8.28, >300-fold selectivity over OX1R. |
| PC-35934 |
Nag 26
|
Nag 26 (Orexin receptor agonist Nag26) is a potent, selective orexin/hypocretin receptor 2 (OX2R) agonist with EC50 of 23 nM, Emax=98%.. |
| PC-42964 |
MK-3697
|
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM). |
| PC-61107 |
Seltorexant
|
A potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively. |
| PC-60755 |
SB-649868
|
A potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively. |
| PC-60752 |
GSK-1059865
|
A highly potent, selective orexin-1 receptor (OX1R) antagonist with IC50 of 5.0 and 6.4 nM for hOX1R and rOX1R, respectively. |
