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Chemical Structure : ACT-541468
CAS No.: 1505484-82-1
Catalog No.: PC-60727Not For Human Use, Lab Use Only.
ACT-541468 (Nemorexant) is a potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
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| 50 mg | Get quote | ||
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ACT-541468 (Nemorexant) is a potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.
ACT-541468 displays high selectivity over a panel of 130 central and peripheral pharmacological targets.
ACT-541468 shows potential for treatment of insomnia disorder.
| M.Wt | 450.927 | |
| Formula | C23H23ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone |
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1. Treiber A, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):489-503.
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