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Chemical Structure : Suvorexant
CAS No.: 1030377-33-3
Catalog No.: PC-60062Not For Human Use, Lab Use Only.
Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
Suvorexant significantly and dose-dependently reduces locomotor activity and promotes sleep in rats.
| M.Wt | 450.92 | |
| Formula | C23H23ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone |
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1. Cox CD, et al. J Med Chem. 2010 Jul 22;53(14):5320-32.
2. Winrow CJ, et al. J Neurogenet. 2011 Mar;25(1-2):52-61.
3. Sun H, et al. Sleep. 2013 Feb 1;36(2):259-67.
4. Hopkins CR. ACS Chem Neurosci. 2012 Sep 19;3(9):647-8.
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