JNJ-10397049 is a potent, selective, and bioavailable OX2 receptor (OX2R) antagonist with Kb of 4.5 nM.
JNJ-10397049 displays >200-fold selectivity over OX1R (Kb=1.1 uM), and has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors.
JNJ-10397049 decreases the latency for persistent sleep and increases nonrapid eye movement and rapid eye movement sleep time in rats
JNJ-10397049 attenuates D-amphetamine-induced relative cerebrovascular signal, with prominent cortical involvement in rat brains.
