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Chemical Structure : JNJ-10397049
Catalog No.: PC-70015Not For Human Use, Lab Use Only.
A potent, selective, and bioavailable OX2 receptor antagonist with Kb of 4.5 nM.
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A potent, selective, and bioavailable OX2 receptor antagonist with Kb of 4.5 nM; displays >200-fold selectivity over OX1R (Kb=1.1 uM), and has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors; decreases the latency for persistent sleep and increases nonrapid eye movement and rapid eye movement sleep time in rats; attenuates D-amphetamine-induced relative cerebrovascular signal, with prominent cortical involvement in rat brains.
| M.Wt | 484.2 | |
| Formula | C19H20Br2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dugovic C, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):142-51.
2. Faedo S, et al. Eur J Pharmacol. 2012 Oct 5;692(1-3):1-9.
3. Gozzi A, et al. PLoS One. 2011 Jan 28;6(1):e16406.
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