Seltorexant (JNJ-42847922) | OX2R inhibitor

Chemical Structure : Seltorexant

CAS No.: 1293281-49-8

Seltorexant (MIN-202, JNJ-42847922, JNJ-922)

Catalog No.: PC-61107Not For Human Use, Lab Use Only.

Seltorexant (JNJ-42847922, MIN-202) is a potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$178	In stock
50 mg	$298	In stock
100 mg	$428	In stock
250 mg		Get quote

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Biological Activity

Seltorexant (JNJ-42847922, MIN-202) is a potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively.
Seltorexant displays an 2-log selectivity over OX1R, and shows no significant affinity for 50 receptor/transporter/ion channel (<50% inhibition at 1 uM).
Seltorexant reduces the latency to non–rapid eye movement (NREM) sleep and prolongs NREM sleep time in rats (3–30 mg/kg).

Physicochemical Properties

M.Wt	407.453
Formula	C21H22FN7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone

References

1. Letavic MA, et al. J Med Chem. 2015 Jul 23;58(14):5620-36.

2. Bonaventure P, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.

3. Yun S, et al. Front Behav Neurosci. 2017 May 8;11:83.

Seltorexant (MIN-202, JNJ-42847922, JNJ-922)

Biological Activity

Physicochemical Properties

References

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