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Chemical Structure : SB-334867 free base
CAS No.: 792173-99-0
Catalog No.: PC-42731Not For Human Use, Lab Use Only.
SB-334867 is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4, displays 50-fold selectivity over OX2R (pKb 5.7).
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|---|---|---|---|
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| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
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SB-334867 is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4, displays 50-fold selectivity over OX2R (pKb 5.7).
SB-334867 also displays >100-fold or selectivity over 5-HT2B, 5-HT2C and approximately 50 other molecular targets, in particular GPCRs and ion channels.
SB-334867 possesses CNS penetration, in vivo activity following ip dosing.
| M.Wt | 319.3174 | |
| Formula | C17H13N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl- |
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1. Smart D, et al. Br J Pharmacol. 2001 Mar;132(6):1179-82.
2. Porter RA, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10.
3. Rodgers RJ, et al. Eur J Neurosci. 2001 Apr;13(7):1444-52.
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