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Chemical Structure : MK-3697
CAS No.: 1224846-01-8
Catalog No.: PC-42964Not For Human Use, Lab Use Only.
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM).
MK-3697 is orally efficacious in sleep experiments across species with high OX2R occupancy and low OX1R blockade.
MK-3697 demonstrated excellent sleep efficacy across species, and shows potential for the treatment of insomnia.
| M.Wt | 447.5096 | |
| Formula | C23H21N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 22.5 mg/mL |
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| Chemical Name/SMILES |
[2,3'-Bipyridine]-4-carboxamide, N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)- |
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1. Roecker AJ, et al. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90.
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