Catalog No.: PC-42964Not For Human Use, Lab Use Only.
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM).
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM).
MK-3697 is orally efficacious in sleep experiments across species with high OX2R occupancy and low OX1R blockade.
MK-3697 demonstrated excellent sleep efficacy across species, and shows potential for the treatment of insomnia.
