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Chemical Structure : SB-649868
Catalog No.: PC-60755Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively.
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A potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively; displays >1,000-fold selectivity for the orexin target receptors in a broad panel of GPCRs, ion channels and enzymes; demonstrates high effectivity in pre-clinical model of sleep disorders.
Sleep Disorder
Phase 2 Discontinued
| M.Wt | 477.554 | |
| Formula | C26H24FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Renzulli C, et al. Drug Metab Dispos. 2011 Feb;39(2):215-27.
2. Bettica P, et al .Neuropsychopharmacology. 2012 Apr;37(5):1224-33.
3. Piccoli L, et al. Neuropsychopharmacology. 2012 Aug;37(9):1999-2011.
4. Di Fabio R, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5562-7.
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