Chemical Structure : SB-649868
CAS No.:
380899-24-1
SB-649868
(SB 649868, SB649868)
Catalog No. : PC-60755Not For Human Use, Lab Use Only.
SB-649868 is a potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively.
Packing Price Stock Quantity 5 mg $118 In stock 0 1 2 3 4 5 10 mg $188 In stock 0 1 2 3 4 5 25 mg $298 In stock 0 1 2 3 4 5 50 mg $488 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6075501
Biological Activity
SB-649868 is a potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively.
Physicochemical Properties
M.Wt
477.554
Formula
C26H24FN3O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide
References
1. Renzulli C, et al. Drug Metab Dispos. 2011 Feb;39(2):215-27.
2. Bettica P, et al .Neuropsychopharmacology. 2012 Apr;37(5):1224-33.
3. Piccoli L, et al. Neuropsychopharmacology. 2012 Aug;37(9):1999-2011.
4. Di Fabio R, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5562-7.
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