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Chemical Structure : Lemborexant
CAS No.: 1369764-02-2
Catalog No.: PC-45062Not For Human Use, Lab Use Only.
An orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
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An orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively; exhibits an overall improvement in properties such as the TDI of CYP3A and aqueous solubility, high OXRs antagonist activity and sufficient brain penetration; demonstrates high efficacy in preclinical sleep experiments.
Sleep Disorder
Phase 3 Clinical
| M.Wt | 410.4166 | |
| Formula | C22H20F2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Cyclopropanecarboxamide, 2-[[(2,4-dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)-, (1R,2S)- |
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1. Yoshida Y, et al. J Med Chem. 2015 Jun 11;58(11):4648-64.
2. Beuckmann CT, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):287-295.
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